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In this context, it is important to understand that for a vehicle to qualify as fully autonomous, it should be able to navigate itself in real traffic within roads which have not been specifically adapted for its use, but this does not mean that there will not be broader modifications to road infrastructure to accommodate the AVs.
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Broad modifications of various positions of the minimal natural epitope recognized by the myelin-associated glycoprotein (MAG), a blocker of regeneration of neurite injuries, produced sialosides with nanomolar affinities.
These broad modifications are prevalent in the human genome [ 16].
Do we observe differences in broad modifications among BTSC types and neural stem cells?
Here, we examine variation in broad modifications among our five cell types.
We find substantial differences among cell types in broad modifications and bivalent promoters.
The mechanisms that create broad modifications are believed to be significantly different from those that create focal modifications [ 22].
Less studied, but prevalent in the human genome, are long regions continuously possessing a epigenetic modification ("broad modifications", [ 16, 22]).
(4) We detected significant and clear changes in broad modification areas for H3K27me3 and, to a lesser extent, for H3K9me3, implying that the processes creating or maintaining these broad modifications differed in activity among cell types; in one case we verified that this change in a broad modification affected gene expression.
To study alterations in broad modifications, we examined the longer regions represented in this microarray format (see Methods; Additional file 34).
Due to the limitations of this microarray format with respect to investigating broad modifications, conclusions around these results must be tentative.
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