Broad endpoints accounted for the diverse range of symptoms potentially associated with recreational water exposure but such broad symptoms may obscure more specific effects of water quality and swimming exposure.
SAVOR also demonstrated neutrality on the broader composite endpoint of CV death, MI, stroke, or hospitalization for unstable angina, heart failure, or coronary revascularization (HR, 1.02 [95% CI, 0.94, 1.11]).
However, the design of this study has been criticised, mainly for failure to measure oxidative stress and vitamin E levels in most of the patients [ 16- 18] and because the study had a small sample size with resultant wide confidence intervals for a broad composite endpoint [ 19, 20].
8 9 10 These results were not confirmed in a reanalysis of another randomised trial using a broad composite endpoint of different cardiovascular events.
Similar point estimates were observed for the broader secondary CV endpoint; however, the upper limit of the 95% CI was <1.3 for all methods.
Generally, a few thousands of MBq of 90Y are injected in the patients, and the 99.98 % of high-energy β−s from the decay produce a very high flux of Bremsstrahlung X-rays, which have a broad spectrum with endpoint 2.279 MeV.
The broad-scaled primary endpoint revealed no significant improvement of axial motor functioning with combined STN+SNr stimulation compared with stimulation on only active subthalamic contacts.
Since the literature on adverse effects of ephedrine is ambiguous about what particular cardiovascular effects to expect (2– 5), we employed a broad, composite primary endpoint and performed secondary analyses on each subset of this endpoint.
In this analysis, overall lifetime risk of cardiovascular disease was somewhat lower in women than in men (38.1% v 43.2% at age 55) and excess risk attenuated for both coronary heart disease and cerebrovascular disease compared with the broad cardiovascular disease endpoint.
Therefore, a broad-scaled primary endpoint was defined as 'axial score' built from eight items of the anamnestic UPDRS II (items 13 15: falling unrelated to freezing, freezing when walking, walking) and the clinical UPRDS III (items 27 31: arising from chair, posture, gait, postural stability, body bradykinesia and hypokinesia), all 5-point rated.
