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Since we are interested in the entire strength of the structure of clusters rather than stability of individual clusters, we added stabilities of the broader clusters to the stability of the cluster which they contained and called it hierarchical stability.
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Subclusters within a general category-such as liberal and conservative blogs clustering within the broader cluster of political blogs-are also interlinked, though less densely than within-cluster connectivity.
In the case of pYVNV, 50% of the population is in the β-turn conformation, 25% of the population forms a slightly broader cluster with a CA-RMSD of 2 Å from the extended conformation, and another 12% lie in a cluster about 6 Å from both the extended and the β-turn conformation, corresponding to a conformation in which the peptide forms a roughly 90° bend towards the CD loop.
The remaining amino acids (R274, E373, H383, and P278) form a distinct, broader cluster of residues situated close to one side of the deep pocket.
The LTK is currently the subject of a broader cluster randomised trial across 58 primary schools within TA Chikowi investigating the effectiveness, cost-effectiveness and feasibility of such an intervention (ClinicalTrials.gov: NCT02213211).
But it is odd that countries should clump together into two broad clusters.
Several broad clusters of traits were identified, which each correlated with a number of context-specific behavioural traits.
At a gross anatomical level, the data driven approach revealed five broad clusters that showed distinct brain-wide functional connectivity.
Cow parsnips are perennials, often several feet high, with large compound leaves and broad clusters of white or purplish flowers.
Classified by these two parameters, which together provide a snapshot of how developed markets are, African countries fall into four broad clusters.
We explore properties of this cis-regulatory change, revealing the role of particular retroelements, uncovering broad clusters of species-biased enhancers near genes associated with human facial variation, and demonstrating that cis-regulatory divergence is linked to quantitative expression differences of crucial neural crest regulators.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com