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Subclusters within a general category-such as liberal and conservative blogs clustering within the broader cluster of political blogs-are also interlinked, though less densely than within-cluster connectivity.
In the case of pYVNV, 50% of the population is in the β-turn conformation, 25% of the population forms a slightly broader cluster with a CA-RMSD of 2 Å from the extended conformation, and another 12% lie in a cluster about 6 Å from both the extended and the β-turn conformation, corresponding to a conformation in which the peptide forms a roughly 90° bend towards the CD loop.
The remaining amino acids (R274, E373, H383, and P278) form a distinct, broader cluster of residues situated close to one side of the deep pocket.
The LTK is currently the subject of a broader cluster randomised trial across 58 primary schools within TA Chikowi investigating the effectiveness, cost-effectiveness and feasibility of such an intervention (ClinicalTrials.gov: NCT02213211).
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Since we are interested in the entire strength of the structure of clusters rather than stability of individual clusters, we added stabilities of the broader clusters to the stability of the cluster which they contained and called it hierarchical stability.
Applied to the 2011 Ambit study [40], the protein kinase targets form a broad cluster, extended along the dimension of the first principal component (Fig. 4).
Students should devise an individual course of study that falls within one of the following four broad cluster categories: 1) Literary and Critical Theory; 2) Form/Genre/Medium; 3) Literature in History; 4) Literature and Culture(s).
The CA-RMSD of the specificity determining segment Val pTyr+1 -Pro pTyr+2 -Met pTyr+3) goes from 4.0±1 Å at 3000K, to 3±1 Å with a cooling rate of 50 ps/step, to 2±1 Å at 500 ps/step; 94% of the population lie in a broad cluster with an average CA-RMSD of 2±1 Å, and 28% of the population in a tight sub-cluster with a CA-RMSD of 0.6±0.1 Å (Figure 2D F and 3D F).
Cluster two grouped the majority 41.5% of the isolates (n= 27), sharing 75.6% similarity and forming a broad cluster.
We found that all 5 studies provided appropriate details on representative sampling and used broad cluster sampling.
The remaining samples (N = 801) used in this study grouped together in a broad cluster of diverse ranges of relatedness.
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