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As a new addition to the palette of advanced imaging modalities, integrated PET/MRI systems need to be validated before a broader clinical application can be accomplished [93].
Low transduction efficiencies in airway cells, immune reactions, and failure to achieve long-term expression in vivo prevented broader clinical application.
However, its broader clinical application in chronic wound assessment is hindered by several limitations.
As a consequence, CARs have the advantage of a broader clinical application in patients with different HLA haplotypes [10].
As the key challenges of T-cell avidity, persistence and ability to exert the desired anti-tumour effects as well as the identification of new target antigens are addressed, a broader clinical application of these therapies could be achieved.
Since the role of hip arthroscopy and consequently the number of surgeons who apply this technique have significantly increased in the recent years our study presents an important impulse towards easier procedures and subsequently broader clinical application [ 25].
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EVOO illustrated significant anti-osteoporosis, antioxidant, anti-inflammatory, and anticancer properties and may have broader clinical applications in the future.
Since their introduction as diagnostic tools, both wrist and shoulder arthroscopy have undergone technical advancement and broader clinical applications.
By targeting the Akt pathway at multiple levels, the miRNAs identified in this study may not only be relevant to HRG signaling as Akt is activated downstream of different cancer-promoting RTKs via conserved mechanisms, implying broader clinical applications.
However, to date there has been no proven technique effective for broad clinical application.
Given the low spatial resolution and limited signal-to-noise ratio, a broad clinical application appears to be difficult.
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