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However experimental work suggests that broader alterations of processing style may also have an impact on related cognitive processes (Watkins and Moulds 2005).
Further factors to be considered in this multifactorial aetiology are chromosomal anomalies; epigenetic effects, both 'narrow' effects on DNA and broader alterations in gene expression; and environmental effects, both general, long term (as nutritional deficiencies) as major, short term insults.
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The nature of the alterations also differs, e.g. focal versus broad alterations.
We defined broad alterations as those spanning >50% of a chromosome arm.
It is reasonable to assume that the RA pathogenesis is influenced by broad alterations of gene expression in general.
Indeed, there have been no systematic attempts to understand the broad alterations in children's psychological well-being as they recover and return to normal activities post-PICU.
Discrepancies between the mRNA and protein expression for several jun/fos genes suggest broad alterations of post-transcriptional processes in the RA SM.
Functional annotation of the protein-coding mRNAs and isoforms indicated broad alterations in immune response, cell activation, metabolic processes, and RNA modification.
It should be noted that such a response does not represent the broad alterations of expression profile generally observed in pre-mortal conditions, as no mortality occurred and all fish gradually recovered when water temperature was backed to 16°C [ 42].
Second, the directions taken by technological trajectories and aggregate demand in advanced economies seem to point toward a broad alteration of the balance of locational advantages for production fragments, decreasing the weight of labor costs and augmenting the relevance of local availability of other complementary intangible assets.
However, their study does not provide a basis for recommending a broad alteration of blood lead screening strategies.
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