Sentence examples for broadened specificity from inspiring English sources

Here we used the Tiam1 PDZ domain and an engineered variant (QM PDZ) with broadened specificity to investigate the role of structure and conformational dynamics in molecular recognition.

A Tar variant that could detect cysteic acid still showed a strong sensitivity to aspartate, indicating that the new receptor had a broadened specificity relative to wild-type Tar.

In this paper, we compare rabbit antibody responses elicited with multi-allele vaccines incorporating seven threee DiCos and four natural AMA1 alleles) and three (DiCo mix) antigens for gains in broadened specificity.

We compare this response with that induced by a similar immunisation with a mixture of seven antigens (the three DiCo proteins and natural AMA1 alleles from FVO, HB3, 3D7 and CAMP strains of P. falciparum) for gains in broadened specificity.

The set of residues which can be mutated to broaden specificity might therefore not coincide with the set of residues which detect differences in DNA sequence.

As predicted, the double mutant I86A/C295A SADH has broadened substrate specificity for meta-substituted, but not para-substituted, acetophenones.

For detection of various haloalkanes we have chosen the R. erythropolis DhA since it is well characterized and it has been reported to display broadened substrate specificity (Koudelakova et al., [2011], Pavlova et al., [2009]).

According to the previous studies on mutagenesis of POx for improved thermostability or broadened substrate specificity (Bastian et al. 2005; Heckmann-Pohl et al. 2006; Masuda-Nishimura et al. 1999), three residues (T166, K312, and E539) of TsPOx were selected for mutation (Additional file 1: Figure S1).

Mutagenesis of these residues broadens specificity, creating a promiscuous adaptor that recognizes an expanded substrate repertoire.

Furthermore, several AR mutations, resulting in increased activity or broadened ligand-specificity to alternative steroids and antiandrogens, have been associated with disease progression [9], [10].

To start with, we described examples of evolved aldolases with broadened substrate specificities.