Sentence examples for broaden specificity from inspiring English sources
The set of residues which can be mutated to broaden specificity might therefore not coincide with the set of residues which detect differences in DNA sequence.
Here we used the Tiam1 PDZ domain and an engineered variant (QM PDZ) with broadened specificity to investigate the role of structure and conformational dynamics in molecular recognition.
A Tar variant that could detect cysteic acid still showed a strong sensitivity to aspartate, indicating that the new receptor had a broadened specificity relative to wild-type Tar.
We compare this response with that induced by a similar immunisation with a mixture of seven antigens (the three DiCo proteins and natural AMA1 alleles from FVO, HB3, 3D7 and CAMP strains of P. falciparum) for gains in broadened specificity.
In this paper, we compare rabbit antibody responses elicited with multi-allele vaccines incorporating seven threee DiCos and four natural AMA1 alleles) and three (DiCo mix) antigens for gains in broadened specificity.
A monoclonal FQ antibody, 6H7, was targeted to random mutagenesis to broaden the specificity of the antibody in development of a generic assay for FQ antibiotics.
These mutations might therefore broaden sequence specificity by relaxing the stringency of a regulatory mechanism.
It seems reasonable to assume that increasing the number of different PfAMA1 alleles included in such a multi-allele vaccine would further broaden the specificity of the expected anti-PfAMA1 antibody response.
However the presence of a second vwb gene may increase clotting activity or help broaden host specificity.
Many of these mutations broaden ligand specificity, and some confer resistance by converting the AR antagonist into an agonist of the mutant receptor (Veldscholte et al., 1990; Haapala et al., 2001; Hara et al., 2003).
There is, therefore, considerable interest in targeting CSCs within tumours with cytotoxic agents as a cure for breast and other cancers and where possible to broaden the specificity of therapeutic agents to treat as wide a patient group as possible.
