Though our approach is generally applicable to broad-spectrum evaluation of middle ear pathology, we demonstrate its utility here using cholesteatoma as the paradigm.
Our protocol consisted of immediate cessation of immunosuppression (if any), best supportive care, broad-spectrum antimicrobials and thorough evaluation to detect reversible causes of deterioration.
Therefore our protocol consisted of immediate cessation of immunosuppression (if any), best supportive care, broad-spectrum antimicrobials and thorough evaluation to detect reversible causes of deterioration.
HCAP was selected for evaluation because broad-spectrum empirical antimicrobial therapy and de-escalation are indicated [ 8].
In studies that will be reviewed in detail elsewhere, our lead O-arylated diazeniumdiolate JS-K (11) has moved into the late preclinical stage of evaluation as a broad-spectrum anticancer drug candidate, active in numerous in vivo rodent models of cancer including leukemia, 28) multiple myeloma, 29) and tumors of the prostate, 28) liver, 30) and lung.
Conclusions: The immunomodulatory properties of WLBU-2 reveal a potential mechanism of its broad-spectrum antibacterial activity and warrant further preclinical evaluation to study bacterial clearance and rescue of chronic inflammation.
Chemotherapy-induced neutropenia may be accompanied by fever, presumably due to life-threatening infection, which generally requires hospitalization for evaluation and treatment with empiric broad-spectrum antibiotics.
The findings clearly demonstrated that phenolic-rich benzene fraction has promising broad-spectrum antioxidant and antimutagenic property and needs further evaluation to exploit its therapeutic potential.
In a health risk evaluation of the measured air concentrations, the broad-spectrum organophosphates chlorpyrifos and diazinon ranked highest in acute inhalation toxicity, after three fumigants with higher vapor pressures (e.g., methyl bromide).
A preliminary evaluation of the efficacy of the selected TLR3 surface as a broad-spectrum viral biosensor was also performed.
Numerous intensive care unit patients have multiple risk factors for developing this infection, which include prolonged hospitalisation, use of broad-spectrum antibiotics, presence of intravascular catheters, parenteral nutrition, high Acute Physiology and Chronic Health Evaluation score, and so forth.
