These modeling results show that the membrane potential changes observed in vivo are broader than those observed in vitro and that the broader time course can be explained by variably-timed inputs (but see Lin et al., 2003; Froemke et al., 2005; Zhang et al., 2009 for alternative sources of broader STDP windows).
In visual cortex samples, where we investigated a broader time course we found a striking resemblance of expression pattern between p1@Mecp2 and p2@Cdkl5 with both genes showing an increase from P14 to P30 and stabilizing from P30 to P60, while the expression of p1@Cdkl5 remained steady.
In broad time-course samples of fetal, neonate and adult human brain sub-regions we found that FOXG1 expression was generally higher in fetal samples (Additional file 6: Figure S5a) while the expression of both promoters of CDKL5 and p1@MECP2 in fetal samples were lower than their expression level in adults (Additional file 6: Figure S5b,c).
The heat map for genes analysed throughout the acute and chronic cuprizone treatment and recovery time course show broad pattern similarity.
Examination of the trajectories showing at least two decreases and no increases over the time course revealed a broad and statistically significant down-regulation of genes involved in cell division and general metabolism in all three prominences between E10.5 E12.5 (Figure 5 and Tables S3A-J).
The 80 Wolbachia genes that exhibited dynamic expression across the modENCODE D. melanogaster life cycle time course fall into three broad classes.
To describe the wound response of A. thaliana in a broad functional context we compared a wounding time course of wild type (wt) plants with that of dde 2 2 mutant plants.
In addition to this broad-period (175 ms) ANOVA, we examined the time course of eye position effects with ANOVA over a short duration sliding time window.
Our time course experiments demonstrated that IL2 exerts a broad range of effects on NK cells ranging from regulation of cell cycle, cell survival, cytotoxicity and secretion of immunologic and inflammatory effectors in a sequential manner.
Furthermore, the HGF+-derived cell lines displayed a slower migration into a "scratch wound" over a 24 h time course, characterized mainly by slow movement of broad adherent cell masses and occasionally single cells (Fig. 5b; Supplemental Video Files 1 6).
Time course analysis of ABA perfusion of growing Arabidopsis roots expressing ABACUS1 reveals broad, concentration-dependent, and reversible cytosolic and nuclear accumulation of ABA, and indicates that ABA treatment accelerates ABA metabolism.
