Sentence examples for broad targeting of from inspiring English sources

Collectively, our results suggest that, as compared to broad targeting of TGFβ, TSP1 may be an ideal therapeutic target for fibrotic diseases such as SSc.

Furthermore, genetic and pharmacological studies have suggested that broad targeting of general TGFβ signaling pathways, although perhaps of benefit in suppressing aspects of the SSc phenotype, might be problematic for treating SSc due to the pleiotropic nature of TGFβ.

These high-confidence targets illustrate the broad targeting of cell proliferation by miR-203 and suggest mechanisms by which loss of miR-203 can facilitate the expansion of oncogenic Hras-transformed cells.

These results are consistent with the fact that, as discussed above, TGFβ is pleiotropic and that broad targeting of TGFβ in humans is likely to have adverse side-effects.

Finally, as discussed above, although these data strongly suggest that the TGFβ ligand-type I receptor axis contributes to the fibrotic phenotype in SSc, broad targeting of the type I TGFβ receptors is likely to be problematic in SSc as the type I receptor generally mediates TGFβ signaling [ 10].

Future strategies should aim for a broader targeting of the PI3K pathway in pancreatic cancer.

The spatially broader targeting of the TH-Cre over the DAT-Cre, the latter of which occurs only in subsets of DA cells and not at all in Vglut2- only cells, may also contribute to the difference in reward-related responses, although mechanisms remain to be established.

In our previous studies, TALENs exhibited remarkable efficiency of gene disruption as well as broad targeting spectrum of DNA sequence in genome [ 5].

Considering the broad targets of GTPγS and GDPβS inside the cell, it is conceivable that the effect of these nucleotides might have been mediated by downstream effectors other than heterotrimeric G-proteins.

The first approach is based on broad-view targeting of "areas of interest" or "red flags".

These BH3 peptides exhibit a broad and multimodal targeting of the BCL-2 family proteins.