In contrast, programs that have broad targeting by industry (e.g., manufacturing), by company type (e.g., small businesses), or groups of workers (e.g., the unemployed) are included.
He did not further explain how those broad targeting guidelines were used in practice.
The broad targeting capability comes from the highly diverse repertoire of sequences encoded by piRNAs (also called 21U RNAs) in C. elegans.
In our previous studies, TALENs exhibited remarkable efficiency of gene disruption as well as broad targeting spectrum of DNA sequence in genome [ 5].
Collectively, our results suggest that, as compared to broad targeting of TGFβ, TSP1 may be an ideal therapeutic target for fibrotic diseases such as SSc.
Furthermore, genetic and pharmacological studies have suggested that broad targeting of general TGFβ signaling pathways, although perhaps of benefit in suppressing aspects of the SSc phenotype, might be problematic for treating SSc due to the pleiotropic nature of TGFβ.
These high-confidence targets illustrate the broad targeting of cell proliferation by miR-203 and suggest mechanisms by which loss of miR-203 can facilitate the expansion of oncogenic Hras-transformed cells.
These results are consistent with the fact that, as discussed above, TGFβ is pleiotropic and that broad targeting of TGFβ in humans is likely to have adverse side-effects.
The recruitment strategy has been intentionally broad, targeting headache specialty care, primary care and non-care populations with migraine to avoid missing qualifying subjects and to include subjects with differing levels of care and a range of migraine symptoms.
