Recently, the therapeutic range (a broader range including 0.5 points below the target ranges) is used besides the target range, since it is assumed to be a better measure for the quality of care considering the OAT [ 15].
The disease has a broad target range, including the economically important grapefruit (Citrus × paradisi), orange (C. × sinensis) and tangerine (C. tangerina).
Hence, it has become increasingly evident that the comprehensive ubiquitinylation process remains a prime target of a broad range of pathogens including viruses.
In our own research laboratory, highly functional scFv antibodies that recognize a broad range of targets, including evolutionarily conserved proteins have been selected and characterized [ 15- 18].
Direct cloning, traditional sequencing, and deep sequencing approaches have discovered many non-conserved miRNAs in rice, and their predicted target genes encode a broad range of proteins, including some transcription factors (Supplementary Table 1).
Non-conserved miRNA target genes encode a broad range of proteins, including a limited number of transcription factors (Table 2, Figure 2C).
This technology enables the study of a broader range of targets, including preclinical candidates, facilitating determination of polymorphism propensity much earlier in the drug development process.
This represents a broader and more severe range than that included in the CFQ-R validation (mean range = 51 – 92) [ 24], but similar to that reported by Bradley et al. (mean range = 2585 85) [ 25].
Neprilysin demonstrates affinity for a broader range of physiological targets, including natriuretic, vasodilatory and neuro peptides [ 71].
BNC1 target genes have been implicated in a broad range of functions including chromatin structure, transcription/DNA-binding, adhesion, signal transduction and intracellular transport [ 61– 63].
Usp9x has emerged as a potential therapeutic target in some hematologic malignancies and a broad range of solid tumors including brain, breast, and prostate.
