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The broad substrate spectrum of HRP and the spontaneous polymerization of radicalized reaction products in particular facilitate the use of HRP in detoxification applications.
Intriguingly, TACE possesses a broad substrate spectrum of growth factor and cytokine substrates, whose cleavage leads to activation of the epidermal growth factor receptor (EGFR) signalling cascade (e.g., TGF- α and amphiregulin) (Yarden, 2001; Sunnarborg et al, 2002; Wang et al, 2009).
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As a whole-cell biocatalyst, the recombinant E. coli BL21 DE3 pLysS (pETDuet-gaccr-gdh) possessed a broad substrate spectrum for kinds of carbonyl compounds with encouraging yield and stereoselectivity.
SULT1A1 is the most abundant SULT in liver and has the broadest substrate spectrum of any SULT.
This is in accordance with the previously shown broad substrate spectrum specificity of the C-P lyase pathway [ 12] in several Pseudomonads, Escherichia hermannii, Bacillus megaterium, Actinomyces spp. and the marine diazotroph Trichodesmium[ 10].
Laccases are regarded as industrially relevant enzymes due to their broad substrate spectrum and wide range of reactions that they catalyze, including cross-linking of phenolic compounds, degradation of polymers, ring cleavage and oxyfunctionalization of aromatic compounds.
As shown in Table 4, AcCR exhibits a broad substrate spectrum and the enantioselectivity of this enzyme follows anti-Prelog rule which are relatively rare in nature (Tang et al. 2014; Li et al. 2015).
Laccases have huge potential for biotechnological applications due to their broad substrate spectrum and wide range of reactions they are able to catalyze.
The data indicate that AHL lactonase has a broad substrate spectrum and digests efficiently all of the 4 tested AHL compounds used in the study, Table 1.
The recombinant AcCR exhibited excellent enantioselectivity, broad substrate spectrum, and highly stereoselective anti-Prelog reduction of prochiral ketones.
Laccases possess a number of advantages including a broad substrate spectrum.
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