Sentence examples for broad substrate specificity catalyzing from inspiring English sources
The stromelysins have relatively broad substrate specificity, catalyzing degradation of many different substrates in the ECM [ 1**, 2**].
Ntg1 and Ntg2 are closely related and, as opposed to Ogg1, exhibit a broad substrate specificity catalyzing the removal of oxidized pyrimidines and purines (26, 27).
Presumably, this reaction [acyl-CoA:retinol acyltransferase activity] is mediated by acyl-CoA diacylglycerol acyl-CoA diacylglycerolnzyme with broacyltransferaseecificity catalyzing the synthesis of triglycerides (TGs), diglycerides (DGs), and waxes [7].
Previous works have shown that SET7/9 exhibits broad substrate specificity catalyzing methyl transfer to a variety of histone and non-histone proteins including H3, TAF10, TAT, RelA, p53 and FoxO3 [ 5, 32].
This is surprising as they display a remarkable substrate specificity catalyzing reactions, which represent a challenge for classic organic chemistry.
Mammalian carboxylesterases (EC 3.1.1.1) belong to a multigene superfamily encoding enzymes that have broad substrate specificity and catalyze the hydrolysis of ester-, thioester-, and amide-bond containing xenobiotic and endogenous compounds.
Interestingly, FMO GS-OX 1 - 4 share broad substrate specificity and catalyze the conversion from methylthioalkyl GS to the related methylsulfinylalkyl GS independent of chain length.
The cytosolic oxidoreductase AKR1A1 has broad substrate specificity, and similarly catalyzes the reduction of aliphatic and aromatic aldehydes, ketones, and xenobiotics [ 80].
A possible (and widely accepted) explanation is that these ancestral enzymes possessed broad substrate specificity, allowing them to catalyze several different chemical reactions (see below).
The PHA synthase of R. eutropha H16 exhibits a very broad substrate specificity (Haywood et al. 1989) and catalyzes the biosynthesis of a wide range of different PHAs and PTEs.
This might be explained by the facts that the enzymes in this group have broad substrate specificity and that the enzymes in this group catalyzing different substrates in species with closer affinity are more similar to each other than enzymes with same functions in distantly related species [ 81].
