Sentence examples for broad substrate selectivity of from inspiring English sources

mfCYP2C93v1 and mmCYP2C93v1 substantially catalyzed diclofenac 4-hydroxylation, flurbiprofen 4-hydroxylation, S-mephenytoin 4-hydroxylation, and tolbutamide methylhydroxylation, but not paclitaxel 6α-hydroxylation (Table 3), indicating a broad substrate selectivity of CYP2C93, unlike human and other macaque CYP2Cs.

Equilibrative nucleoside transporters exhibit a broad substrate selectivity for both purine and pyrimidine nucleosides and appear to be ubiquitous in mammalian cells.

To the best of our knowledge, EPHX1 plays an important role in the majority of xenobiotic metabolisms and ensures widespread defense against potentially genotoxic epoxide intermediates including vitamin K epoxide, which is attributed to its exceptionally broad substrate selectivity [ 18].

The substrate selectivity of MRP1 is quite broad, allowing MRP1 to confer resistance to anthracyclines, epipodophyllotoxins, vinca alkaloids, and camptothecins [21].

Therefore, substrate selectivity of CYP2C93 appears to be broader than human and other monkey CYP2Cs.

We examined substrate selectivity of CYP1s expressed in yeast.

It is the tendency towards strengthening of the substrate selectivity of MCF that makes the enhancement of selectivity of the H+ substrate.

The enhancement of substrate selectivity of MCF offers a possible way to reduce oxygen damage.

However, the molecular mechanism of substrate selectivity of MCs remains incompletely understood.

Structural comparison of TySemiSWEET and LbSemiSWEET provides important clue to understanding substrate selectivity of SemiSWEETs.

Different substrates require distinct surface residues for binding, affording a first glimpse into the substrate selectivity of human O-GlcNAcase.