Sentence examples for broad substitution from inspiring English sources
In general, all PADs/FDC tolerated a remarkably broad substitution pattern on the aromatic system (1a– 8a, entries 1 8), whereas modification of the styrene side chain in the α- or β-position was detrimental (9a, 10a, 16a and 17a, entry 9).
A broad G+C substitution mutation was previously described to test the functional importance of ARS elements [24].
These observations are consistent with a scenario in which high GC content results from broad-scale substitution bias rather than selection for specific GC-rich codons.
In some regions such as Eastern Europe, significant increases in polyunsaturated fat and reciprocal declines in saturated fat intake were identified between 1990 and 2010, demonstrating feasibility of such broad population substitutions to reduce coronary heart disease risk.
A broad G+C rich substitution mutation for ARS elements was used in reference [24].
This mode of molecular evolution agrees with the understanding that most proteins are substantially tolerant of a broad spectrum of substitutions and thus may harbor many amino acid sites available for evolutionary modification [ 37].
Among a broad variety of bone substitution substances calcium sulphate/carbonate bone substitution beads proved to be a suitable osteoconductive material for bone reconstruction [ 15, 16].
Therefore, we used a broad range of linear substitution rates of 1.5 3% My-1 reported for bird studies [ 13, 55].
Their flexibility in accommodating a broad range of atomic substitutions provides to these oxides a wide variety of properties while keeping its basic structure unchanged.
Our broader sampling of nrITS substitution rates allowed us to analyze more fully potential sources of variation in these rates.
Importantly, our broad-scale analysis of substitution patterns across a diverse array of viruses also revealed a negative association between the estimate of ti/ tv and the age of the root-node in the case of RNA viruses, again indicative of site saturation.
