Either way, our results suggest that, like adults, there is a broad spectrum of variation in the adolescent brain, and so aggregate conclusions about brain maturity may lead to imprecise generalizations of what is appropriate or inappropriate for adolescents to do [53].
Because this study involves the analysis of taxa of disparate levels of divergence, a data set was assembled that consisted of nuclear loci (two ribosomal RNA genes and the histone H3) and a mitochondrial ribosomal RNA locus, that in combination span a broad spectrum of variation.
Due to their close phylogenetic relationship, Brassica-Arabidopsis comparative genomics promises to identify genetic determinants of a much broader spectrum of variation than might be accessible using Arabidopsis alone [ 12- 14].
Consider ambiversion (balanced interactivity), introversion (covertness, recessiveness) and extroversion (overtness, assertiveness) as basic personality types, but running a broad scope or full spectrum of variations.[3] Those called ambiverts appear noticeably well-rounded, balanced and not extreme in either regard (recessive or assertive).
Evidence has come from different study designs, such as nuclear families, twins, multigenerational families, and case-control samples, together examining the broad spectrum of genetic variation including cytogenetic abnormalities, copy number variants, genome-wide association of common variants, and sequencing studies targeting rare and/or de novo variation.
While theoretical mechanisms for the transport and incorporation of both U and Pb in speleothem calcite remains a matter of debate, it is clear that natural samples span a broad spectrum of compositional variation, and likely contain Pb components with multiple origins and/or transport pathways.
Advanced genetics approaches and sequencing tools have identified a broad spectrum of genetic variation in the coding region of human genes.
Thus, Old World monkeys display a broad spectrum of KIR haplotype variation that has been generated upon an ancestral haplotype architecture by gene duplication, gene deletion, and non-homologous recombination.
Alternative hybrid approaches can overcome limitations of alignment-consensus methods [ 13, 14], allowing to capture a broader spectrum of sequence variation comparing genome with or without reference genome [ 15].
The advantage of iPSCs technology is that it allows the generation of various cell lines that may represent the genetic and potentially epigenetic variation of a broad spectrum of the population.
Compared with dendrimers, liposomes, and other organic/inorganic nanoparticles, polymeric micelles are much more versatile to deliver a broad spectrum of therapeutics because of their enormous chemical variation, relative easy preparation, multiple functionality, high drug loading capacity, and small particle sizes (10 100 nm).
