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6-Methoxy-3-(3′,4′,5′-trimethoxybenzoyl)-1H-indole 6-Methoxy-3- 3′,4′,5′-trimethoxybenzoyl -1H-indolelymerization which exhibits both in vitro and in vivo activities against a broad spectrum of solid tumors.
The mTOR inhibitors have demonstrated clinical activities in a broad spectrum of solid tumours.
Mimics of let-7 and miR-34 are under preclinical development to target a broad spectrum of solid tumors.
When exposed to pemtrexed, a broad spectrum of solid cancer cells are arrested, mainly in the S-phase, and subsequently become apoptotic.
Gemcitabine is a nucleoside analogue with activity against a broad spectrum of solid tumours, such as pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovary cancer (Hertel et al, 1990).
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The new regime has some unique characteristics including intensive gas solids interaction, high gas solids contact efficiency, two peaks of probability density distribution (PDD) curves in the center of the fluidized bed, broader spectrum of solids holdup for PDD curves, a decreasing extent of gas solids separation extent and unique radial detail wavelet energy percentage profiles.
This suggests that the Nutlin+17AAG combination might resurrect Nutlin as a clinically viable uniform platform against a broad spectrum of wtp53-harboring solid tumors.
CIS-Diamminedichloroplatinum (cisplatin) is a commonly used cytotoxic agent with a broad spectrum of activity against solid malignant tumours, including germ cell, ovarian, endometrial, cervical, urothelial, head/neck and lung cancer.
PEG, the hydrophilic moiety, is a non-toxic, non-immunogenic hydrophilic polymer that prevents interactions with cells and proteins [ 13]. 5-Fluorouracil (5-FU), a pyrimidine analogue that interferes with thymidylate synthesis, has a broad spectrum of activity against solid tumors.
Gemcitabine is a deoxycytidine analogue that has a broad spectrum of antitumour activity in many solid tumours including pancreatic cancer.
Gemcitabine (dFdC, 2′,2′-difluoro-2′-deoxycytidine) is a deoxycytidine analogue with a broad spectrum of anticancer activity against several solid tumours in preclinical models (van Moorsel et al, 2000), and it is now an established effective agent in the treatment of NSCLC and pancreatic cancer (Noble and Goa, 1997).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com