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In this study, we performed a comprehensive GOLPH2 protein expression analysis in a broad spectrum of normal and malignant tissues.
The ribonucleases (RNases) are ubiquitous, conserved enzymes that function in a broad spectrum of normal physiological processes, such as host immune responses.
It regulates a broad spectrum of normal essential biological functions, including DNA damage repair, cell proliferation, cell cycle progression, cell renewal, cell differentiation, cell migration, angiogenesis and cell survival.
DRAM-3 is expressed in a broad spectrum of normal tissues and tumor cells, but different from DRAM-1, DRAM-3 is not induced by p53 or DNA-damaging agents.
Investigation of a broad spectrum of normal and malignant tissues by RT PCR revealed the TSPY transcript selectively expressed in normal testis, different histological types of human neoplastic tissues, and tumour cell lines.
One report used a bead-based detection platform to profile expression of 217 miRNAs in a broad spectrum of normal human tissues, but low sensitivity and specificity make the results problematic for miRNAs that are less abundant [ 14].
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Our results confirm the equivalence of both measurements in their capacity to rank diabetic patients with a broad spectrum of lipid values, from normal to frank dyslipidemia with elevated atherogenic cholesterol (non-HDL-C) and/or atherogenic particles number (apoB).
The discovery of cancer/testis (CT) antigens, which express in a broad spectrum of neoplasms but not in normal tissues except in testis and placenta, has provided new perspectives for antigen-specific immunotherapy (Scanlan et al, 2002).
For the last two decades, evolution in molecular biology has expanded our knowledge in decoding a broad spectrum of genomic imbalances that progressively lead normal cells to a neoplastic state and finally to complete malignant transformation.
This study points out the great need for thorough characterization of cell nanoparticle interactions as subtle time-dependent effects are hard to monitor and commonly used viability and functionality assays are not sufficient to address the broad spectrum of possible interferences of the nanoparticle with normal cell functioning.
This phenomenon might account for the broad spectrum of effects ascribed to this oncogene in normal and tumor cells [ 10, 11].
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