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The underlying challenge is the lack of state-of-the-art models applicable to broad spectrum of microbial organisms for accurate description of treatment history.
Toll-like receptors (TLRs) are evolutionarily conserved membrane-bound pattern recognition receptors (PRRs) that recognize a broad spectrum of microbial components such as lipopeptides and non-self nucleic acids [1].
Since toll-like receptors have been shown to recognize a broad spectrum of microbial products as well as DAMPs [2], [3], we investigated their involvement in the reduction of skeletal muscle I/R injury provided by rhBCL2 or rhBCL2A1.
Twenty three of them were produced as synthetic analogs among which some exhibited activity against a broad spectrum of microbial pathogens (Pöppel et al. 2015).
MLST is a multilocus sequence-based genotyping protocol that has been widely used to investigate the population structures of a broad spectrum of microbial species ranging from bacteria and archaea to eukaryotic microbes [ 14, 15].
Previous reports indicated that mindin-deficient mice had an impaired capability to clear influenza virus and bacterial infection, and mindin-deficient macrophages exhibit defective responses to a broad spectrum of microbial stimuli.
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Such modification modulates the function of a broad spectrum of mammalian, plant, and microbial proteins.
Although originally discovered in the pituitary gland and named for its effects on pigmentation more recent studies revealed that α-MSH interacts with different types of cells such as macrophages, neutrophils or epidermal cells resulting in a broad spectrum of functions including anti-microbial, anti-inflammatory, as well as immunomodulatory activities [4] [9].
Neutrophils possess a broad spectrum of weapons against viral and microbial pathogens including compounds of neutrophil granules (defensins, elastase, and some others), reactive oxygen species (ROS), and orthomyxovirus resistance gene (Mx) proteins [ 15, 16].
They are also natural antibiotics that exhibit rapid, potent and long-lasting activity against a broad spectrum of pathogens by affecting conserved features of microbial cell membranes [ 1].
Taken together, these diverse and overlapping floral habitats provide a broad spectrum of available vectors and niches for microbial nectar-colonizers on a small regional scale.
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