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In human tissues, LMO4 has a very broad spectrum of expression (14).
The average interquartile range (IQR, distance between 25th and 75th percentiles) was 3.0, indicating that the patient's carcinomas had a fairly broad spectrum of expression measurements (average of 3 fold difference between the 25th and 75th percentiles).
Results: We present a software package named Oases designed to heuristically assemble RNA-seq reads in the absence of a reference genome, across a broad spectrum of expression values and in presence of alternative isoforms.
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Despite potential confounding effects - arising out of tissue, species and experimental diversity - in the reported data, I analyzed the data under the assumption that genes in diverse human studies when combined together would capture a broader spectrum of expression changes in DS and hence be appropriate enough for uncovering potential PTZ mechanism.
Sox2-Lkb1 tumors exhibited a broad spectrum of TTF1 expression, ranging from no TTF1 expression (similar to human SCCs) to higher levels of expression.
This finding is in contrast to the broad spectrum of CLDN1 expression found in other human tissues, such as liver and pancreas (our unpublished data).
A surprisingly broad spectrum of clinical expressions is observed in humans ranging from asymptomatic to cutaneous (CL), diffuse cutaneous, mucocutaneous and visceral (VL) diseases, and an intermediary form known as post-Kala-Azar dermal leishmaniasis.
We included a broad spectrum of gene-expression studies, including ones that are (1) cross-sectional or longitudinal design, (2) on different microarray platforms, (3) on whole blood or purified leukocytes, (4) in healthy volunteers or infected human hosts, and (5) paediatric or adult patients.
Treatment with MT201 for several months at high trough levels may provide ample time for MT201 to recruit immune effector cells for elimination of tumour cells with a broad spectrum of Ep-CAM expression levels.
These two cell types were chosen in order to identify a broad spectrum of specific gene-expression changes that could result from inhibition of UCH L1 expression.
An additional hierarchical cluster analysis identified broad spectra of gene expression patterns during seed development.
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