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Whereas transcriptome profiling of neutrophils allows one to work with a relatively homogeneous cell population, PBMC represents a broad spectrum of cell types that may vary in numbers between individual patients.
Because both the ligand and the receptor are expressed on a broad spectrum of cell types, we set out to study the expression of CD200 and CD200R on CD11b+ monocytes, granulocytes, and subsets of T lymphocytes.
Embryonic stem cells (ESCs) represent a potentially unlimited source of chondrocytes and tissues as they can generate a broad spectrum of cell types under appropriate conditions in vitro.
They do not induce proliferation or activation of T cells [36], [37], act in a broad spectrum of cell lines and potently repress CXCR4 chemokine receptor expression and function [38].
It is known that both compounds possess a broad spectrum of cell damaging properties besides the DNA damage [ 13, 14].
As an efficient bioinformatics tool, RPdb will assist in the discovery of novel reprogramming factors in a broad spectrum of cell reprogramming research.
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Based upon this analysis, and without needing to isolate the individual cells, we have defined a broad spectrum of cell-type and pathway-specific gene signatures present in cancer expression data which were also found to be largely conserved in a number of independent datasets.
Lentiviral vectors (LVs) can efficiently transduce a broad spectrum of cells and tissues, including dividing and non-dividing cells.
Thus, it appears that BLV can infect a broad spectrum of cells, although its receptor(s) remains unknown.
In this mouse model, tamoxifen causes PTEN excision in a broad spectrum of cells, leading to the development of multiple malignancies.
To identify lectins that are useful for identifying and separating hPSCs in mixed cell populations, we systematically profiled the glycoproteins in a broad spectrum of cells (Table 1) using lectin microarrays.
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