Sentence examples for broad specificity of the from inspiring English sources
We also provide molecular evidence for the plasticity of the TAS2R16 binding site and an explanation for the relatively broad specificity of the receptor.
The results with EgKU-8 complement detailed studies of the interaction of BPTI and its mutants with classical serine proteases [18], [35], which have elucidated the structure-function relationship and broad specificity of the Kunitz family.
This may also support the broad specificity of the enzyme.
In view of the rather broad specificity of the frog isomerase, we made a databank search for potential substrates of such an enzyme.
In light of the broad specificity of the MMP substrate used in the initial experiments, the source of the increased MMP activity was investigated further by utilizing a second substrate with specificity for MMP-12 and MMP-13.
However, none of them has been developed successfully as anti-AD drugs mainly because of deleterious side effects; the broad specificity of the MMP inhibitors must be a stiff obstacle for developing safe and effective drugs.
It is particularly interesting that the linkage region around 220 cM on chromosome 2 showed minor peaks for Cd and Se as well as the suggestive one for Zn, perhaps reflecting the broad specificity of this transporter.
The structure of chondroitinase ABC I provides a framework for probing specific functions of active-site residues for understanding the remarkably broad specificity of this enzyme and perhaps engineering a desired specificity.
The reason for this discrepancy arises likely from the broader specificity of the RET-P1 antibody used by Won et al. In contrast to the 1D4 antibody, RET-P1 is known also to label the cell bodies, fibers and synaptic pedicles of rod photoreceptors and such labeling may cause easily the misinterpretation of data of mutant mouse strains, such as Rpgrip1 nmf247.
Opsonization occurs through the broad specificity of IVIG, and the formed immune complexes are effectively cleared through the effects of peptide stimulation (including modulation of phagocytic Fcγ receptors) on phagocytes (4, 5).
A structural model of pro-falcipain-2 was constructed by homology modeling based on crystallographic structures of mature falcipain-2, procathepsin K, procathepsin L, and procaricain, offering insights into the nature of the interaction between the prodomain and mature domain of falcipain-2 as well as into the broad specificity of inhibitory activity of the falcipain-2 prodomain.
