Sentence examples for broad specificity of from inspiring English sources

The structure of chondroitinase ABC I provides a framework for probing specific functions of active-site residues for understanding the remarkably broad specificity of this enzyme and perhaps engineering a desired specificity.

However, the mechanisms that support the broad specificity of DcR3 remain to be fully defined.

The initial inhibitors were pre-existing clinically used compounds and exploited the broad specificity of P-gp.

In addition, comparison of the SMYD2 ERα and SMYD2 p53 structures provides the first structural insight into the diverse nature of SMYD2 substrate recognition and suggests that the broad specificity of SMYD2 is achieved by multiple molecular mechanisms such as distinct peptide binding modes and the intrinsic dynamics of peptide ligands.

This is similar to the apparent broad specificity of ERAD E3s in targeting different proteins in the ER for degradation.

However, we observed broad specificity of serum IgG responses in both male and female badgers in immunoblots of T. pestanai lysates.

This also explains the broader specificity of BRDs as each domain is able to recognize more than one peptide that shares some degree of amino acid variations.

40 There is a need to better understand whether this relates to the broader specificity of aflibercept as compared to single-targeted bevacizumab; this could form the basis for the logical use of these agents in sequence.

The reason for this discrepancy arises likely from the broader specificity of the RET-P1 antibody used by Won et al. In contrast to the 1D4 antibody, RET-P1 is known also to label the cell bodies, fibers and synaptic pedicles of rod photoreceptors and such labeling may cause easily the misinterpretation of data of mutant mouse strains, such as Rpgrip1 nmf247.

First, we analyzed total splenic RNA using real-time RT-PCR with a primer-probe set of broad specificity for MLV-related RNA sequences.

This finding also suggests that an ancestral enzyme with broad specificity for the synthesis of ribonucleotides and deoxynucleotides could have been utilized in the LCA.