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Alternatively, they may serve as a platform to regulate a broad set of genes, which are subsequently fine-tuned by specific regulators.
Instead, it binds to a largely distinct, and broad, set of genes.
Therefore, nuclear RNAi maintains stable expression of a broad set of genes under heat stress.
Alternatively, ubiquitous GmNACs might serve as a platform to regulate a broad set of genes which are subsequently fine-tuned by specific regulators.
Alternatively, and perhaps most commonly, ubiquitous TFs might serve as a platform to regulate a broad set of genes, which are subsequently fine-tuned by specific regulators.
The genus Solanum has a broad set of genes, including the PR-5 protein family, with the potential to confer resistance to pathogens [ 4].
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In future work, it will be important to build from these findings to understand how this broad set of gene expression changes are integrated to promote formation of a normal sized compartment of cells.
Custom arrays allow researchers to focus on broad sets of genes or gene polymorphisms specific to particular cell populations, signalling pathways or disease conditions, while providing ultimate control over the experimental design.
With current data it is not possible to say to what extent the observed results may apply to a broader set of genes or to other tissues.
However, by transactivating a few miRNAs, each of them possibly targeting hundreds of mRNAs, p53 activation may indirectly lead to the post-transcriptional repression of a much broader set of genes.
Many of these networks were constructed using experimental data combined with literature mining, with the aim of identifying a broader set of genes involved in a particular cardiovascular disorder.
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