The tight spatial and temporal control of the formation and dissipation of these higher-order structures involves a broad set of actin-binding proteins, like filamins, Arp2/3, cofilin, profilin and capping proteins, all regulating specific steps of actin dynamics [4], [6].
All aptamers were characterized under identical conditions (10 mM HEPES, 150 mM NaCl, and 5 mM MgCl2 at pH 7.4 and 25 °C), enabling the first direct comparison of the binding properties of a broad set of small molecule-binding aptamers.
It should be mentioned that the idea of using the matching of linear codes, as embodied in our sequence-matching rule, to model the satisfaction of a broad set of requirements for the binding of proteins to other molecules, is not entirely new.
It is now time to apply them to a broader set of peptide binding proteins, to provide a comprehensive picture of the linear motifs in the human proteome and to link them to their potential binding partners.
We next applied genome-wide chromatin immunoprecipitation (ChIP -chip analyses to extend the Snail-1-binding studies to a broad set of target promoters at multiple time points following Snail-1 induChIP -chipe points: 0, 6, 48, analyseshr).
PGC-1α has multiple binding partners and is thereby able to simultaneously induce transcription of a broad set of genes, most of which are involved in energy metabolism and redox handling, including Prx3 and Trx2 [ 23, 24].
Finally, RNA or peptide binding could increase the specificity of a reaction: metal ions such as Fe(II) act on a broad set of substrates.
It also issued a broad set of reforms to improve its compliance practices.
"We've had a very broad set of asset price changes".
Google uses a "broad set of signals" to deliver recommendations.
People could solve a broad set of business problems.
