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This arrangement of receptors is largely responsible for the broad responsiveness of the trigeminal nerve and also provides redundant detection mechanisms for many chemicals.
Terminal differentiation of NK cells is crucial in maintaining broad responsiveness to pathogens and discriminating normal cells from cells in distress.
The broad responsiveness of the SCCs at the entrance duct may be advantageous for monitoring a variety of chemicals in the fluids destined to the VNO, because of the complexity of the natural stimuli and the potential for contamination by a wide range of chemicals when bodily secretions are deposited in the environment.
Our approach to quantify the broad responsiveness of ex vivo cytokine production was previously described [ 17].
The results informed our hypothesis that the broad responsiveness of one or more immune pathways is associated with the potential of the inflammatory process to mediate joint destruction.
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The metabolism of cells in 3-D microwells was upregulated compared to cells with the same substrate stiffness and extent of cell spreading on 2-D surfaces (Fig. 5), suggesting that altered cytoskeleton assembly may hint at a broader responsiveness of cells to 3-D adhesion.
Third, within the intensity-invariant cell population there is an overall tendency that the invariant cells exhibiting general or broader responsiveness to multiple episodic events have much stronger firing cross-correlations than those of cells that respond only to a specific event.
Platelet-function profiling performed exclusively in type 2 diabetic patients receiving aspirin and clopidogrel therapy has shown that even though these patients compared with nondiabetic subjects have higher degrees of platelet reactivity, there is still a broad range of responsiveness (46).
COX-2 as a product involved in proinflammatory actions of the chondrocyte itself was selected because of its broad and differential responsiveness to all drugs, its potent downregulation by glucocorticoids, and its exceptional role in current treatment strategies of rheumatic diseases.
The higher number of SCCs in the upper airways implies higher sensitivity or a broader range of responsiveness in that region.
A concurrent nested study design [ 26] was adapted to enable the researchers to gain broader perspectives of responsiveness, by adding a qualitative open-ended question to the quantitative questionnaire.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com