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Inhibition of host-encoded targets, such as the cyclophilins, provides an opportunity to generate potent high barrier to resistance antivirals for the treatment of a broad range of viral diseases.
Antibodies (Abs) produced during HIV-1 infection rarely neutralize a broad range of viral isolates; only eight broadly-neutralizing (bNt) monoclonal (M Abs have been isolated.
Modulation of host cell apoptosis is an important immune escape mechanism employed by a broad range of viral, bacterial and parasitic pathogens.
We hypothesized that RIT targeted against viral antigens could be used in the treatment of a broad range of viral infectious diseases and virus-associated tumors [15], [16].
The results presented here suggest that, when individuals throughout a broad range of viral loads and blood CD4 counts are evaluated, there are significant relationships between antiviral mucosal effector responses (both individually and in combination), and both VL and CD4.
In a previous study focused primarily on IFN-γ production, we reported that rectal CD8+ T-cell responses to Gag were immunodominant (as compared to Pol and Env) in chronically infected subjects not on antiretroviral therapy with a broad range of viral loads [26].
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It has the same methodological characteristics but a broader range of viral analytes than the U.S. FDA-approved version.
In 2007, we expanded testing at the two refugee camps to include other respiratory viruses, with the aim of determining a broader range of viral aetiologies of acute respiratory infections (ARI).
Here, our hope is that the rapidly increasing number of sequencing projects will also provide us with a larger number and a broader range of viral metagenomes in the sequence databases.
A broad range of structural viral proteins has the ability to assemble into virus-like particles (VLPs).
MBL is an important innate defense molecule active against a broad range of bacterial, viral, fungal and protozoan pathogens [ 30].
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