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It is rendered possible by the presence of V1a receptors in smooth muscle cells, over a broad range of vascular beds.
Chromosome 9p21 has recently been shown to be a risk region for a broad range of vascular diseases.
This study validates that sequestration occurring in deep microvessels during CM involves a broad range of vascular cells, particularly platelets, erythrocytes, monocytes and endothelial cells.
Thus, further understanding of the molecular sensors and downstream signaling pathways that control flow-dependent remodeling is relevant to a broad range of vascular dysfunction.
Out of these ten representative species in a broad range of vascular plants, including fern, conifers, monocots and dicots, the CODEHOP strategy thus provided CYP98-related DNA sequences in seven cases.
Molecular imaging of endothelial adhesion molecules has been at the forefront of this field, since the upregulation of these molecules is an early event in a broad range of vascular diseases including atherosclerosis, ischemia-reperfusion injury, ischemic stroke and cancer.
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SMCs produce a broad range of immunoinflammatory mediators contributing to vascular inflammation [ 6] and participate in the formation of arterial tertiary lymphoid tissue in experimental atherosclerosis [ 7].
Its ligand, OX40L, is expressed on a broad range of cell types, including dendritic, vascular endothelial, natural killer, mast and B cells.
The HIFα/β dimer binds to a core DNA motif in the hypoxia responsive elements, which are associated with a broad range of target genes, such as vascular endothelial growth factor (VEGF), erythropoietin (EPO), and glucose-transporter-1 (GLUT-1), promoting angiogenesis, erythropoiesis, cell growth and migration, and a switch to a glytolytic cell metabolism [ 6].
Finally, epidemiological studies have linked migraine with and without aura to a broader range of ischemic vascular disorders including angina, myocardial infarction, coronary revascularization, claudication and cardiovascular mortality [28].
Recent evidence has also linked migraine to a broader range of ischemic vascular disorders including cerebral ischemia stroke, angina, myocardial infarction, coronary revascularization, claudication, and cardiovascular mortality [ 26].
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