Safe, effective adjuvants that enhance vaccine potency, including induction of neutralizing Abs against a broad range of variant strains, is an important strategy for the development of seasonal influenza vaccines which can provide optimal protection, even during seasons when available vaccines are not well matched to circulating viruses.
Damaging variants in the Swiss-Prot dataset include not only casual variants for Mendelian disease but also variants associated with complex diseases, thus covers a much broader range of variants that may have a functional impact.
Human diseases are caused by alleles that encompass the full range of variant types, from single-nucleotide changes to copy-number variants, and these variations span a broad frequency spectrum, from the very rare to the common.
The evaluated forms cover a broad range of popular variants.
In 2005 Mark G. Charest and co-workers in the department of chemistry and chemical biology at Harvard University reported a method for synthesizing a broad range of structural variants of tetracycline.
DOI: http://dx.doi.org/10.7554/eLife.00662.020 We found substantial variation in many of these phenotypes between isolates in the same series, supporting the notion that the isolates are samples from a broad range of genetic variants within clonal (single infection) populations.
Most commonly, students had used their raw data to assess their relative risk for conditions known in their family history, but all participants also mentioned mining their data for a broad range of reported variants, using outside sources, such as SNPedia http://www.snpedia.com/index.php/SNPedia.snpedia.com/index.php/SNPedia
This allows the detection of a broad range of isolates and variants of the H5N1 subtype.
MIRU and RFLP analysis of several hundred other cases of XDR-TB found in other provinces in South Africa show a broad range of different genotypes, including variants of M. tb strain families Haarlem, EAI, LAM, and X [4].
Generally, a broad range of different A-type rif variants was detected in each experiment at similar frequencies, indicating that there is no clear dominance of single variants in any of the stages (Fig. 5, Table 2).
