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Therefore, we decided to explore reactivity of PPh3/I2 with bis-alkoxymethanes (1) and herein efficient synthesis of a broad range of structurally diverse α-alkoxymethyl triphenylphosphonium iodides (2) is being reported (Scheme 1b).
For more investigations, a broad range of structurally diverse benzoyl chlorides 2 was condensed with 2-amino-3-hydroxy pyridine 1 under room temperature (Method A) and also at conventional heating (Method B).
P-gp confers resistance to a broad range of structurally diverse chemotherapeutic drugs by contributing to resistance phenotype by drug efflux from cancer cells [ 33].
It can transport a broad range of structurally related or unrelated compounds including anticancer drugs out of cells and thereby decrease intracellular accumulation of these compounds.
Capable of transporting a broad range of structurally and chemically diverse compounds from the cell, these proteins afford simultaneous resistance to multiple cytotoxic compounds and drugs.
108, 128, 129 CHO-lysate-based CFPS systems have enormous potential for the efficient and economic production of a broad range of structurally and functionally diverse proteins.
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Since the BCRP effluxes a wide range of structurally diverse xenobiotic compounds from cells [12], the broad distribution of BCRP not only renders less complete distribution of drugs but also causes a poor response of cells to chemotherapeutics [13 15].
High throughput screening (HTS) programs have demonstrated that the Vitamin D receptor (VDR) is activated and/or antagonized by a wide range of structurally diverse chemicals.
In contrast, the heterogeneous polyimmunity loci contain a wide range of structurally unrelated immunity proteins.
The cytochrome P450 enzyme CYP1A2 plays a main role in the metabolism of a variety of structurally unrelated compounds, including a broad range of different drugs, and its activity is widely modulated by a plethora of inducer/inhibitor molecules.
This BINOL ZnEt2 Ti(OiPr)4–catalysttalysystemtem can be used to catalyze the reaction of structurally diverse alkynes with a broad range of aldehydes at room temperature with high enantioselectivity and good catalytic activity.
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