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In recent years, a broad range of serum and urinary enzymes and proteins have been proposed as possible early biomarkers of drug-induced nephrotoxicity [32], also through the use of proteomic methods [33].
Nevertheless, DKA patients can present with a broad range of serum potassium concentrations.
The large size of this cohort, together with the broad range of serum PFC values, provides unique opportunities for investigating associations between PFCs and human health.
The use of antibody microarrays directed against a broad range of serum and lung tumor proteins would have utility for elucidating those proteins with the greatest diagnostic utility.
To address this question, we used a comprehensive collection of samples from the HORIZON II trial (Hoff et al, 2012), which provided the largest sample set to date from a randomised study and enabled retrospective exploration of a broad range of serum biomarkers at baseline, and their relevance to treatment outcome and disease.
Discovery of biomarkers through the analysis of patient serum or tissue is a conventional approach being used since the beginning of diagnosis of cancer, but the broad range of serum proteome and availability of patient tissue samples are the major hurdles.
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This broad range of palivizumab serum trough concentrations highlights the wide interpatient variability observed in subjects: 25% of infants had serum trough concentrations <40 µg/mL before dose 5.
The 84 antibodies targeted 80 different proteins, present at a broad range of concentrations in serum, that could have levels associated with lung cancer, including acute phase reactants, proteases and protease inhibitors, immune system proteins, glycoproteins, extracellular matrix proteins, and cytokines.
In addition to lipid-regulating actions, niacin has a broad range of effects: it increases serum concentrations of glucose, insulin, and uric acid and long-term treatment with niacin is associated with increased plasma free fatty acid (FFA) levels and some of these effects may offset the beneficial effects of niacin on cardiovascular risk [ 19].
Luminex analysis for a broad range of cytokines performed on serum of mice from the 2 week study on days 1, 7, and 14 of NVP treatment revealed an increase in interferon-gamma (IFN-γ) in plasma samples of male mice on day 7, both in animals that developed significant necrosis and those that did not, but the level was highest in an animal that did develop necrosis.
Therefore, patients with CCD-sIgE display a broad range of cross-reactions when subjected to serum investigations.
More suggestions(15)
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