A large scale protein protein interaction study indicated a potential interaction between SerRS and sirtuin 2 (SIRT2) (Ewing et al., 2007), a NAD+-dependent histone deacetylase of the sirtuin family that regulates a broad range of processes, including transcription, metabolism, neurodegeneration, and aging (Finkel et al., 2009).
However, this capability also depends on a well-conserved toolkit of different molecular mechanisms that offer not only compensatory responses to a changing world, but also provide plasticity to achieve changes in cellular state that underlie a broad range of processes from early developmental transitions to life-long memory.
Furthermore, depletion of ER glutathione was without effect on two sensitive, broad-spectrum UPR reporters, arguing that glutathione is indeed dispensable to a broad range of processes required for protein folding homeostasis in the ER of cultured mammalian cells.
The hydrophobins are cell-wall proteins that are secreted by filamentous fungi and have roles in a broad range of processes in growth and development [ 25].
Moreover, the JmjC domain-containing proteins are involved in a broad range of processes.
Future experiments will focus on identifying the direct molecular targets of Cdk5-p35 kinase that link it to each of the broad range of downstream processes that together make up neurodegeneration.
Instead, they are intended to be examples of the broad range of social processes that regulate drug transactions.
Caregivers need to keep an open eye for the broad range of infectious processes that can cause febrile illnesses and local complications.
Mean mass density, morphology and structure were investigated within a broad range of process parameters.
The biological significance of tripartite motif (TRIM) proteins is increasingly being appreciated due to their roles in a broad range of biological processes that associated with innate immunity.
