Sentence examples for broad range of pathological from inspiring English sources

Non-NMDA receptor-mediated excitotoxicity has been proposed to contribute to neuronal loss in a broad range of pathological conditions including hypoxia, hypoglycemia, ischemia, epilepsy, trauma [52], [53], amyotrophic lateral sclerosis [54], Huntington's disease [55], and Alzheimer's disease [56], [57].

Therefore, the addition of a secondary animal model showing a broad range of pathological features might be necessary at later stages of TB drug development to assess drug activity against persisting bacteria in necrotic lesions.

This reactive lipid intermediate has been found in a broad range of pathological conditions and damages mitochondria in cells by increasing proton leak and inhibiting electron transfer [ 17].

Oxidative stress is a phenomenon involved in a broad range of pathological conditions of the nervous system such as Alzheimer's and Parkinson's disease, stroke and trauma.

However, dysregulation of this response, with resulting persistent or inappropriate inflammation, underlies a broad range of pathological processes, from inflammatory dermatoses to type 2 diabetes and cancer.

In addition to these properties, nilvadipine has shown efficacy against a broad range of AD pathological mechanisms, including τ-phosphorylation, reduced cerebral blood flow and neuroinflammation.

"Tuning" gene's expression to keep balance might be one of the important functions of miRNAs, however, it seems hard to reconcile with the reported critical functions of miRNAs in a broad range of biological and pathological processes.

Our findings have significance for a broad range of physiological and pathological processes involving CXCR4 signaling.

Human prion diseases including sporadic, inherited and infectious forms are highly heterogeneous in terms of their broad range of clinical and pathological phenotypes [ 12].

As one of the major effector mechanisms of innate immunity, the complement system is involved in a broad range of physiological and pathological processes, such as clearance of immune complexes and chronic inflammation.

It is thought that the MMP9/TIMP1 system could be involved in a broad range of physiological and pathological phenomena in various brain regions, including developmental reorganization of the cerebellum, hippocampus-dependent learning and long-term potentiation [ 57].