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Antimicrobial peptides (AMPs) are a class of host-defense molecules that neutralize a broad range of pathogens.
Co-expression of transgenes encoding antimicrobial proteins (AMPs) with different biochemical targets is an attractive approach to attain resistance against a broad range of pathogens.
It is feasible to construct a biodefense platform combining synergistic agents that activate the innate immune system against a broad range of pathogens on the basis of conserved microbial components by using a nasal spray for immune activation in the respiratory and gastrointestinal tracts because these are the most likely routes of attack.
We show that germline-deficient strains display increased resistance across a broad range of pathogens including Gram positive and Gram negative bacteria, and the fungal pathogen Cryptococcus neoformans.
This extensive genetic diversity serves as a mechanism whereby the human immune system, on both the individual as well as on a population basis, is equipped to recognize a vast array of epitopes from a broad range of pathogens.
The induced expression of AtWAKL10 by both biotrophic (P. syringae, P. infestans, E. cichoracearum and G. orontii) and nectrophic (B. cinerea, and OGs) pathogens and their related elicitors further indicates a role for AtWAKL10 against a broad range of pathogens.
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Consistent with the induction of the gene group in response to a broad range of pathogen derived elicitors, the expression of AtWAKL10 and the ECGG50 was also induced following inoculation with bacterial, fungal and oomocyte pathogens including both biotrophs and nectrotrophs (Figures 6 8).
The DC maturation process consists of the up-regulation of co-stimulatory molecules, an increase in surface peptide-MHC complex half-life and the production of inflammatory cytokines, and is triggered by a broad range of pathogen-associated molecular patterns (PAMPs).
The immune system of vertebrates has evolved the ability to mount highly elaborate responses to a broad range of pathogen-driven threats.
Among the differentially expressed NBS-LRR genes in each transcriptome set, Glyma01g04000 was differentially expressed at all four transcriptomes and Glyma05g09440 and Glyma06g40980 were differentially expressed at three transcriptomes, suggesting that those NBS-LRR genes may work against broad range of pathogen attack.
As such, the pattern of variability in A. gambiae and Drosophila immune systems is consistent with the recognition of relatively few motifs conserved across broad ranges of pathogens.
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