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At the same time point, we observed a broad range of infection states in myd88−/− embryos, varying from complete clearance of the bacteria (28%) to highly infected (30%) and lethally infected (4%).
The second signal required for NLRP3 activation consists of a broad range of infection or stress-associated signals, and due to the diverse nature of these signals, it is unlikely that direct interactions with NLRP3 would induce its activation [ 197].
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A bacteria fighter, Trovan had shown promise against a broad range of infections--sinusitis, bronchitis, gonorrhea and pneumonia.
Group A Streptococcus (GAS) causes an exceptionally broad range of infections in humans, from relatively mild pharyngitis and skin infections to life-threatening necrotizing fasciitis and toxic shock syndrome.
Across much of the developing world, it costs just a few dollars to buy drugs like amoxicillin, a first-line antibiotic that can be used against a broad range of infections, from bacterial pneumonia and chlamydia to salmonella, strep throat and Lyme disease.
As it can cause broad range of infections it requires a broad range of therapeutic strategies.
However that study included only a select number of AE and included a broad range of infections types.
We considered how relevant our observations might be to a broad range of infections by examining whether additional microbial species also modified presentation to type B T cells.
The species can cause a broad range of infections, most frequently skin and soft tissue infections, such as wound infections, furuncles, carbuncles and abscesses, but also life-threatening systemic infections, such as pneumonia and sepsis [ 1– 3].
As there is a diversity of TLRs [ 12] with differing ligand specificities, responses for a panel of different receptor-ligand combinations may give indications of immune responsiveness towards a broad range of infections.
Primary care physicians and physicians in A&E Departments and Infectious Disease Departments must be aware that both recently arrived and more settled migrants may present with a broad range of infections.
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