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Existing biclustering algorithms do not allow targeting a particular pathway45, 46, instead they generally try to find biclusters that cover either a broad range of genes or conditions.
As each miRNA targets broad range of genes, minor changes in miRNAs can have great effects, contributing to cell transformation.
The broad range of genes that respond to environmental stress is evident in this genome-wide map of genes that are up or down-regulated when fruit flies are exposed to the heavy metal cadmium.
It is commonly known that inactivation of certain tumor-suppressor genes occurs as a consequence of hypermethylation within the promoter regions and a numerous studies have demonstrated a broad range of genes silenced by DNA methylation in different cancer types.
The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two members of the nuclear receptor superfamily that regulate a broad range of genes involved in drug metabolism and transport.
This study was based on the "Sanger Mouse Genetics Project" in their institute to study new roles for a broad range of genes by generating more than 900 knockout mice (White et al., 2013).
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They have been safely used clinically and are efficient for a broad range of gene therapy applications.
A broad range of gene delivery systems are available to researchers involved in pluripotent stem cell manipulation.
(2010), a broad range of gene products was included.
The GO annotations enriched in State 2 show a broad range of gene activities.
Genomic sequence assemblies are key tools for a broad range of gene function and evolutionary studies.
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