Together with published studies examining the effects of related and conventional substances, these results demonstrate that L-CNC and L-CNF are relatively non-toxic for the broad range of endpoints considered, much like their conventional cellulosic counterparts.
That may be one reason why both CRIC and STRIDE will evaluate a broad range of endpoints (e.g., surrogate measures of renal function, composite clinical endpoints, quality of life, etc).
The device mesh moves beyond the traditional desktop computer and mobile devices (tablets and smartphones) to encompass the full range of endpoints with which humans might interact.
Pre- and postconditioning hormesis dose/concentration-response relationships are reported for 154 diverse conditioning agents, affecting more than 550 dose/concentration responses, across a broad range of biological models and endpoints.
TSCA mandates have resulted in "more than 50,000 studies covering a broad range of health and ecological endpoints" being filed with the U.S. EPA since 1976 (U.S. EPA 2003a).
Recently, several researchers made considerable advances in hormetic mechanisms to prove hormesis a highly plausible phenomenon (Hashmi et al. 2014b; Calabrese 2013), and suggested that hormetic responses may be activated by receptor-mediated or cell signaling-mediated hormetic mechanisms, affecting a broad range of cell types and endpoints.
1, 2 In the Phase 3 DEFINE 3 and CONFIRM 4 trials, DMF 240 mg twice daily (BID) and three times daily (TID) demonstrated efficacy across a broad range of clinical and MRI endpoints over a 2-year time period, combined with an acceptable safety profile.
Strengths of the PETRA study are the rigorous study design with a large sample size, adequately powered for the primary endpoint survival, and a broad range of assessments, including gold-standard methods for physical fitness and physical activity.
The Neurologic Academic Research Consortium is an international collaboration intended to establish consensus on the definition, classification, and assessment of neurological endpoints applicable to clinical trials of a broad range of cardiovascular interventions.
Principal stratification has now been applied in a broad range of areas, including HIV; cancer; ophthalmology; orthopedics; mental health; nephrology; surrogate endpoints; noncompliance with missing outcomes; and effects of vaccines on viral load for those infected.
The combination of the Nanovisor and the endpoint-aware network, in turn, combine to provide the ability to create a broad range of disruptive offerings, such as Ad Integrity, as well as new ways to improve the security and performance of web and app interactions.
