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First, SPs provide optimal and model-free reduction of big data for a broad range of downstream analyses.
Finally, we briefly discuss the broad range of downstream products and models that utilized this rapid source characterization.
These transcription factors have been implicated in cooperatively activating or repressing a broad range of downstream target genes [11].
For example, NfkB1 is known to affect expression of broad range of downstream genes involved in various biological processes including immunity, differentiation, and programmed cell death.
This broad range of downstream effects that can be mediated by the CRISPR machinery provides a variety of powerful tools to fine tune the control of bacterial populations.
Future experiments will focus on identifying the direct molecular targets of Cdk5-p35 kinase that link it to each of the broad range of downstream processes that together make up neurodegeneration.
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However, aspirin has a much broader range of downstream effectors, such as NF-KB, insulin-like growth factor I and many others, as well as the inhibition of Wnt signalling and stem cell growth possibly as the result of enhanced beta-catenin phosphorylation (Dihlmann et al, 2001, 2003; Wang et al, 2006).
As a result, they are not acting to specify a broad range of distinct downstream functions as proposed in the histone code hypothesis [ 85].
Gene transcripts which were down regulated showed significant enrichment of miR-34a binding sites in the 3'UTR; however, the additional increase in gene expression indicates the broad range of genes which are affected, downstream of direct target binding, which might be involved in miR-34a-induced apoptosis.
The activated serine-threonine kinase AKT regulates a broad range of target proteins involved in a variety of downstream signaling pathways [15].
Downstream caspases ultimately degrade a broad range of cellular proteins and apoptosis is finalized (for review see [ 29]).
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