However, these data are either confined to the neural progenitor cell state or in vitro represent a broader range of differentiation states (and cell types) at each time point than may be present at one time and place in the embryonic neural axis.
This in turn can induce a broad range of cellular responses including differentiation, migration, proliferation and apoptosis [ 6].
GSK-3β has been implicated in multiple biological processes because it phosphorylates a broad range of substrates including several differentiation checkpoints including c-Myc, snail and PI3K [ 23].
The evaluated populations covered a broad range of scenarios with various degrees of differentiation and depending on whether they were in mutation-migration-drift equilibrium or not.
Metabolites within a broad range of pathways contributed to the differentiation of healthy from diseased individuals, as well as between disease phenotypes (Fig. 2A, Table 1).
The NF-κB family of transcription factors [p65, p50, p52, RelB, and c-Rel] is involved in the activation of a broad range of genes involved in inflammation, differentiation, tumourigenesis, metastasis, embryonic development, and apoptosis [ 11, 12, 14].
Ubiquitination is a major player in regulating a broad range of cellular processes, including cell division, differentiation, signal transduction, protein trafficking, and quality control [24], [25].
Our study demonstrates that loss of Brg1 disrupts Polycomb repression of Hox clusters, as well as a broad range of other developmental regulators, during ESC differentiation.
Signalling through mitogen-activated protein kinases (MAPK) is involved in a broad range of cellular processes, such as proliferation, differentiation, stress responses and apoptosis.
Accumulating evidence shows that miRNAs function in a broad range of biological processes, including development, cellular differentiation, proliferation, metabolism and apoptosis [ 1, 6- 8].
