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In the recent decades, nanoparticles have received considerable attention, largely due to their broad range of bioactivities and distinctive mode of action [23].
Due to the broad range of bioactivities ascribed to propolis, it has long been used in traditional medicine [ 10].
This 53 amino acid peptide shows a broad range of bioactivities on the intestinal epithelium, including the stimulation of cellular proliferation, differentiation, and intestinal maturation [ 16].
In particular, the Subsection V cyanobacteria are well known for the production of the hapalindole-family of compounds, a group of structurally related indole alkaloids consisting of hapalindoles, welwitindolinones and fisherindoles which display a broad range of bioactivities [ 5, 6].
Secondary metabolites from the benzofuran class are known to exhibit a broad range of bioactivities [16 18,20,21], however, an influence on eNOS activity was not described so far.
Plant secondary metabolites from the benzofuran class are known to exhibit a broad range of bioactivities, including anti-inflammatory [16,17], cardio- and vaso-protective [18,19], cytostatic [20], and antioxidant actions [21,22].
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Furthermore, pigmented Pseudoalteromonas species possess a broad range of bioactivity associated with the secretion of extracellular compounds, several of which include pigment compounds (Holmström and Kjelleberg 1999).
Flavonoids are a broad class of phenolic compounds mainly found in plants with a wide range of bioactivities [ 1].
They show a wide range of bioactivities including anti-cancer, anti-inflammatory, antiviral and immuno-enhancing effects.
Many pyrazole derivatives were found to possess a wide range of bioactivities, such as anti-viral and anti-tumor [5 7].
Glycosylated natural products display a wide range of bioactivities including insecticidal [ 62] and antitumor [ 63] activity, amongst others [ 64].
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