Sentence examples for broad range of apoptotic from inspiring English sources

Our data suggest the up-regulation and stabilization of Mcl-1 are crucial events for the apoptosis resistance of C. trachomatis-infected cells for a broad range of apoptotic stimuli.

Increased expression of Bcl-xL in cancer has been shown to confer resistance to a broad range of apoptotic stimuli and to modulate a number of other aspects of cellular physiology, including energy metabolism, cell cycle, autophagy, mitochondrial fission/fusion and cellular adhesion.

Downstream, the function of Noxa converges into an apoptotic signaling cascade involving Mcl-1 and Bim, which are involved in a broad range of apoptotic stress responses.

To determine whether S1 triggers mitochondrial apoptosis, we studied the drug's effects on Bax / Bak /– (DKO) MEFs, which exhibit resistance to a broad range of apoptotic stimuli (Lindsten et al, 2000).

Although it is possible that the poorly understood Bax/Bak-related Bok induces cell death under these specific circumstances, this appears unlikely given that cells from Bok-deficient mice respond normally to a broad range of apoptotic stimuli.

The few survivors exhibited several phenotypic abnormalities, including webbed feet, substantial neuronal and lymphoid cell accumulation, as well as profound resistance of their lymphocytes (and other cell types) to a broad range of apoptotic stimuli.

Over-expression of the Bcl-xL protein is known to confer resistance to a broad range of potentially apoptotic stimuli arising during cancer development, such as oncogene activation, hypoxia and matrix detachment [1] [3].

Most TCM products currently used in cancer therapy display a broad range of biological effects including pro-apoptotic activity, inhibition of angiogenesis and boosting of immune response.

Furthermore, PED/PEA-15 has a broad range of antiapoptotic ability, being able to inhibit both the intrinsic and extrinsic apoptotic pathways [ 171, 173].

A growing body of evidence strongly indicates that both simulated and authentic weightlessness exert a broad range of effects on mammalian tissues and cells, including impairment of immune cell function and increased apoptotic death.

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