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The explored kinome was extended with broad profiling using the DiscoveRx and Millipore assay panels.
GC-MS (gas chromatography-mass spectrometry; Agilent 6890 GC coupled to an Agilent 5973 MS-System, Agilent, Waldbronn, Germany) and LC-MS/MS (liquid chromatography-MS/MS; Agilent 1100 HPLC-System (Agilent, Waldbronn, Germany) coupled to an Applied Biosystems API4000 MS/MS-System (Applied Biosystems, Darmstadt, Germany)) were used for broad profiling, as described in [21].
We developed a novel and efficient method for the in vitro production, visualization, and broad profiling of histone-PTMs of human and murine NETs.
UVPD has gained widespread acceptance as a frontier higher energy MS/MS technique that rivals or in some cases outperforms conventional CID methods for both broad profiling of biopolymers and more selective chromophore-mediated approaches.
Three types of mass spectrometry analysis were applied to all samples: GC-MS (gas chromatography-mass spectrometry) and LC-MS/MS (liquid chromatography-MS/MS) were used for broad profiling [ 13], while SPE-LC-MS/MS (solid phase extraction-LC-MS/MS) was applied for the determination of catecholamine and steroid hormone levels.
As described by van Ravenzwaay et al. (2007) and Kamp et al. (2012a), EDTA-K3 blood samples of all rats taken on study day 28 were analyzed in regard to their metabolite profiles upon metabolite extraction by a proprietary method: GC MS and LC MS/MS were applied for broad profiling and hormone measurement.
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Mrs. Mortimer has an unusually high — or rather, broad — profile for an Upper East Side society woman.
But the method has been less precise than many advertisers would like, because existing Web ad networks create only broad profiles of Internet users, based on visits to selected sites and certain keyword searches.
Contagion was a certainty to open top, given that The Help was entering its fifth weekend and Lionsgate's new release Warrior contains two upcoming leads who lack a broad profile.
The detailed neurocognitive test battery facilitated us to achieve a broad profile of the sample, supporting the study's strength.
Topiramate, through a broad profile of action, might act at different levels: reducing nociceptive transmission through trigeminovascular modulation, and inhibiting cortical spreading depression [20, 21].
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