The laboratory maintains a broad profile of service: prenatal testing, postnatal constitutional analysis and testing for acquired abnormalities (neoplasia).
UVPD has gained widespread acceptance as a frontier higher energy MS/MS technique that rivals or in some cases outperforms conventional CID methods for both broad profiling of biopolymers and more selective chromophore-mediated approaches.
The general focus of Aachen University is on interdisciplinarity, and its broad profile is ideal for tackling cross-cutting research issues addressing global challenges.
These include better risk estimation and treatment optimization, diagnostics that can screen high risk patients to identify a specific disease early, and tests that provide healthcare providers and payers with a broad risk profile for a specific disease to identify appropriate patients for a given targeted therapy.
The sensor has a broad spectral profile for two fluorescent proteins, hence, when the several sensors are present at the same location, imaging without the significant spectral overlap is difficult.
The same group also reported that MRP7 has a broad resistance profile for natural product agents, conferring high levels of resistance to docetaxel (46-fold), paclitaxel (116-fold), SN-38 (65-fold), daunorubicin (7.5-fold), etoposide (11-fold), and vincristine (56-fold) [167].
Three types of mass spectrometry analysis were applied to all samples: GC-MS (gas chromatography-mass spectrometry) and LC-MS/MS (liquid chromatography-MS/MS) were used for broad profiling [ 13], while SPE-LC-MS/MS (solid phase extraction-LC-MS/MS) was applied for the determination of catecholamine and steroid hormone levels.
GC-MS (gas chromatography-mass spectrometry; Agilent 6890 GC coupled to an Agilent 5973 MS-System, Agilent, Waldbronn, Germany) and LC-MS/MS (liquid chromatography-MS/MS; Agilent 1100 HPLC-System (Agilent, Waldbronn, Germany) coupled to an Applied Biosystems API4000 MS/MS-System (Applied Biosystems, Darmstadt, Germany)) were used for broad profiling, as described in [21].
As described by van Ravenzwaay et al. (2007) and Kamp et al. (2012a), EDTA-K3 blood samples of all rats taken on study day 28 were analyzed in regard to their metabolite profiles upon metabolite extraction by a proprietary method: GC MS and LC MS/MS were applied for broad profiling and hormone measurement.
