In contrast, the presentation of the variation in only one or a few metabolites fails to capture the broader patterns of change in composition that the presentation of the variation in the biomarker metabolites provides.
The broad patterns of segmented changes are very similar, and there are several within-chromosome changes that are very closely matched; for example, on 2p, 8p, 11q, and 16q.
In order to assess whether the correlation between our predictions and changes in metabolite concentration was due to these broad patterns of expression changes versus the modulation of specific genes, we performed a permutation analysis designed to assess the specificity of our results (Fig. 1b).
Studying the broad patterns of gene expression change in these later stages of seed development can yield important insights into the processes of seed filling, desiccation, and preparation for quiescence and germination.
Gene expression in BMP4-treated Dicer-null and wild-type NS cells was compared to their untreated counterparts and the expression data first explored by clustering methods to identify the broad patterns of gene expression changes following BMP4 treatment.
A key feature of these evaluations, therefore, is the more distant perspective that the authorial voice takes as its vantage point from the historical landscape, evaluating the terrain in terms of broad patterns of cause, time and change.
The new low, scientists said, was caused by record high atmospheric temperatures, but is part of the broad pattern of climate change that is rapidly altering the Arctic.
These mechanisms may well have changed and adapted in response to the AIDS epidemic, and to broader patterns of social change.
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The broad pattern of the results for IL6 and cortisol will require confirmation, but lack of significant changes in other cytokines was consistent across all the patients studied.
