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Dr. Winzeler, whose results were published in last week's Science, said she had observed the same broad pattern of gene control as Dr. DeRisi.
The broad pattern of gene misexpression suggests intriguing mechanisms creating the dominance pattern of the X. laevis genome in hybrids.
This approach allowed us to identify loci that may be involved in generating the sterility phenotype and simultaneously examine the broad pattern of gene expression in hybrids compared to the parental species.
Considering that there are about 13 times more ESTs in T than in N, it is reasonable to believe that at least 50% increased ESTs in T library could be ascribed to redundancy, suggesting that increased EST was not the unique answer for the broad pattern of gene expression in cancers.
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This is an unavoidable cost of designing an array to detect broad patterns of gene presence.
Gene expression in BMP4-treated Dicer-null and wild-type NS cells was compared to their untreated counterparts and the expression data first explored by clustering methods to identify the broad patterns of gene expression changes following BMP4 treatment.
PCA was conducted to identify broad patterns of gene expression and genes that best discriminate sex and life stage groups.
HPGT1-HPGT3, threcentlyntly identified Hyp- O-GALTs for AGPs that lack GALECTIN domains, were also included in this analysis and showed equally broad patterns of gene expression [ 17].
Studying the broad patterns of gene expression change in these later stages of seed development can yield important insights into the processes of seed filling, desiccation, and preparation for quiescence and germination.
The application of this concept, made possible by CHAP 2, therefore permits an exploration of the broader pattern of gene conversion within the human lineage and beyond (for trends noted in the New World monkeys, see Supplementary Material online).
The broad pattern of p53 target gene expression and apoptosis in the shh−/− mutant at 10somite stage argues against cell death due to differentiation failure, since few cells in the wild-type embryos express neuronal differentiation marker HuC at this stage [55].
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