For example, somatic disruption of KEAP1/CUL3 E3-ubiquitin ligase complex components also promote activation of NF- κB in lung cancer, by compromising degradation of the NF- κB activator, IKBKB [ 24]; given the extensive functions of NF- κB, this may have broad implications to a multitude of biological systems of particular relevance to cancer.
Beyond apoptosis, the activities of these proteins have broad ramifications into a multitude of signaling pathways including MAPK, ErbB and p53.
These results are discussed in the broader context of the multitude of factors that should be considered in assessing the merits of various grading systems, and ultimately the authors recommend the continuation of pass-fail grading at UCSD School of Medicine.
37 This effect measure is multi-dimensional (ie, pain, physical, social, and emotional) and is capable of capturing the broader impacts from a multitude of symptoms relating to uterine fibroids (eg, bulk, pain, and bleeding) alongside the adverse effects of pharmacotherapy.
"He has a broad interest and addresses a multitude of different challenges and problems," he adds.
As it has been established that PML-NBs orchestrates a broad spectrum docking scaffold for a multitude of nuclear proteins in order to regulate their activity and AKT is prominent of them, we felt interested to look for whether alike PP2a, PML could interact with another well-established phosphatase of AKT, viz.
However, the DHI-N is a broader self-report measure, including a multitude of items, while gait tests are performance based and provide separate measures of gait.
But this conceptual reductionism, which was common throughout the period from Sidgwick to Ross, Broad, and Ewing, contrasts sharply with the multitude of concepts recognized in much present-day ethics.
Insects detect a multitude of odors using a broad array of phenotypically distinct olfactory organs referred to as olfactory sensilla.
Thus, the differential diagnosis of renal dysfunction in patients with HIV has become very broad, and its management complex, given the multitude of anti-retroviral therapies in use and their risk of interaction.
It is also impossible to extricate the Mideast conflict from the multitude of links to the broader theme of Islam and the West.
