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While the studies on GIV-GEF indicate that it may be an unusual hub for convergent multi-receptor signaling for the broad modulation of the "disease network", and raise our hope that the GIV●Gαi-interface may serve as an effective target for therapy, several hurdles lie ahead of us before such a possibility can be realized.
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This result again suggests that targeting certain subgroups along the immunologic spectrum might be beneficial not only in targeted cytokine therapy, but also in the broad modulation of inflammatory cytokines via hemofiltration and absorption.
The indazole ether core tolerated a broad range of substituents allowing for modulation of the physiochemical parameters.
Typically the high-band was recreated by upsampling of the low-band signal without subsequent low-pass filtering (aliasing), or by means of broad-band frequency translation (single side-band modulation) of the low-band signal [2, 3].
Attentional rate modulation occurred for a broad range of the gAMPA gNMDA ratios, whereas attentional modulation of the gamma band activity was restricted to a relatively narrow range of gAMPA gNMDA ratios.
Here we showed that artemisinin resistant parasites are characterized by a specific modulation of the IDC transcriptome that affects a broad spectrum of genes and biological functions.
The modulation of the barrier height would provide a route for designing fast and high responsive Schottky photodetector with broad linear dynamic range performance.
Dopaminergic modulation of the superior colliculus.
This form of quadrature modulation accomplishes the simultaneous amplitude and phase modulation of the chrominance subcarrier.
(e) Our model predicted low modulation of the SS modulation but failed to reproduce initial and trained firing frequencies.
Modulation of the thermogenic effect of nutrients by fenfluramine.
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