Sentence examples for broad modifications are from inspiring English sources

These broad modifications are prevalent in the human genome [ 16].

The mechanisms that create broad modifications are believed to be significantly different from those that create focal modifications [ 22].

In contrast, clear changes in broad modifications were much less prevalent for H3K9me3 (4 of 44) and were absent for meC and H3K4me3 (0 of 44 in each case).

This broad modification was restricted to H3K9me3 and was not present with H3K27me3 in this region.

Representative genomic tracks highlighting H3K27me3 enrichment for each sample that exemplify two major categories of gene‐associated H3K27me3 enrichment, that is, the focussed promoter peak and broad regional modification, are shown in Fig.  1.

Further modifications are inevitable, but officials say the broad outlines are already clear.

Further modifications are almost inevitable.

First, not all loan modifications are equal.

Mortgage modifications are, in theory, appealing.

Modifications aren't cheap, though.

Moreover, the "modifications" are all rather radical.